Pfizer and the Depo-Provera Lawsuit

What is Depo-Provera?

Depo-Provera is a brand name for medroxyprogesterone acetate, a hormonal contraceptive given as an intramuscular injection every three months. It is widely used for birth control, managing menopause symptoms, and treating certain medical conditions such as endometriosis.

The shot works by preventing ovulation, thickening cervical mucus, and thinning the uterine lining, making it difficult for sperm to reach or fertilize an egg. It’s praised for its convenience and long-term protection—but that may come with significant risks.

If you’ve ever used Depo-Provera—also known as the Depo shot—and were later diagnosed with a meningioma, you may want to read carefully. Recent findings have raised serious concerns about the long-term safety of this popular injectable contraceptive.

re difficult for sperm to fertilize an egg. While Depo-Provera offers a convenient alternative to daily birth control pills, concerns are growing over the serious long-term side effects.

A meningioma is a tumor that develops in the meninges, the protective membranes surrounding the brain and spinal cord. While most are benign (non-cancerous), their growth and location can cause severe neurological complications, such as headaches, vision problems, memory loss, and even seizures.

Recent studies suggest a potential link between prolonged Depo-Provera use and the development of meningiomas […]

Recent studies suggest a potential link between prolonged Depo-Provera use and the development of meningiomas—particularly in women who received the shot for 12 months or longer, or after at least four injections. Though the exact mechanism is still under investigation, the data has raised enough concern that lawsuits are now being filed against the drug’s manufacturer.

Women across the country are taking legal action against Pfizer, the manufacturer of Depo-Provera, alleging that the company failed to warn about the risk of developing meningiomas. These lawsuits claim that Pfizer knew or should have known about the dangers of long-term Depo-Provera use—but chose not to disclose them to healthcare providers or patients.

Important: This is not a medical malpractice casedoctors are not the defendants. The legal focus is on Pfizer’s alleged negligence in failing to provide sufficient warnings about the risks of meningiomas.

As more affected women step forward, these lawsuits have been consolidated into a multidistrict litigation (MDL) in the Northern District of Florida. This allows multiple cases to move forward efficiently while still maintaining each person’s individual legal rights.

What is a failure to warn claim?

Under U.S. law, drug manufacturers have a legal obligation to inform both doctors and patients of known risks. When they fail to do so, they can be held liable under what’s called a failure to warn claim.

This type of lawsuit:

  • Does not claim that the drug itself is defective
  • Does not accuse doctors of wrongdoing
  • But does argue that Pfizer withheld vital safety information that could have helped women make informed healthcare decisions

Plaintiffs in the Depo-Provera lawsuits allege that:

  • Pfizer was aware of the increased risk of meningiomas with prolonged use
  • The company failed to warn doctors and patients
  • Women suffered serious harm, including the need for brain surgery, because they unknowingly continued using the drug

How did pfizer allegedly fail to warn?

According to the lawsuits, Pfizer’s failure to warn was deliberate and placed profits over patient safety. Some of the alleged actions include:

  • Not updating warning labels even after research showed a link to meningiomas
  • Withholding information from healthcare professionals, preventing them from giving informed advice
  • Providing no public alerts to warn women about possible brain tumor risks

If Pfizer had issued appropriate warnings, women could have chosen alternative treatments and potentially avoided life-altering health issues.

Lawsuits are currently being filed against the manufacturers of Depo-Provera. If you:

  • Took Depo-Provera for birth control, menopause, or other medical purposes,
  • Received the shot for at least 12 months or four injections,
  • And were later diagnosed with a meningioma,

you could be eligible for compensation.

How to get help

Our team is now working with individuals who have been diagnosed with meningioma after using Depo-Provera. Our goal is to connect affected individuals with our qualified legal team that operates on a “no win, no fee” basis—meaning you don’t pay unless we successfully secure compensation for you.

If this situation applies to you or a loved one, it’s time to take action. You can start the process by accessing our Depo-Provera page and filling out the form to have your case reviewed by professionals who specialize in pharmaceutical litigation.


You’re not alone. Help is available—and you have the right to seek justice.

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Meningioma brain tumors and their link to Depo-Provera
"CT scan showing eight axial cross-sections of a human brain. The images appear to depict a large mass effect on the right hemisphere, consistent with a possible meningioma. The tumor causes midline shift, compression of the lateral ventricle, and surrounding edema. The scan may be used to illustrate the presence of a brain tumor and its potential impact on nearby structures

Meningioma brain tumors and their link to Depo-Provera

In recent years, there’s been growing awareness around meningioma, a type of